Lukáš Čajánek, Principal Investigator
Dr. Lukáš Čajánek is a head of the group, situated at the Department of Histology and Embryology at Masaryk University. He got his MSc. degree at the Faculty of Science at Masaryk University, studying cell cycle regulation in mouse embryonic stem cells (mESCs) under supervision of Aleš Hampl. For his Ph.D. studies he joined the lab of Ernest Arenas at Karolinska Institute in Stockholm, Sweden, where he elucidated the role of Wnt signaling in differentiation of mESCs into dopaminergic neurons. In addition, he identified and characterized downstream signaling modules responsible for the particular effects of Wnt ligands.
After defending his Ph.D. thesis in 2011 he joined the lab of Erich Nigg at the Biozentrum of University of Basel in Switzerland for his postdoctoral training to study various aspects of centriole and primary cilia biogenesis. Projects pursued towards this direction led to (1) identification of E3 ligase Mib1 as a novel regulatory element of centriole duplication cycle,(2) identification and functional characterization of tubulin-binding interface of members of anterograde transport complex, IFT81 and IFT74 (in collaboration with Esben Lorentzen lab, MPI Munich, Germany), and (3) identification of the centriole appendage protein Cep164 as a substrate and recruiting factor for Tau tubulin kinase 2 (TTBK2), a protein kinase that is critical for ciliogenesis and implicated in human disease.